WHY THIS INVESTMENT IS IMPORTANT
NCDs present a rapidly expanding worldwide public health and development crisis. NCDs in LMICs are plunging families into poverty, damaging productivity, threatening economic growth and national economies, further straining health budgets and health systems, and putting very substantial U.S. corporate and global health investments at risk. Barring intervention, this problem will only increase in the future. An estimated 15 million NCD-related deaths occur before age 70, and more than 85% of these premature deaths occur in LMICs; NCD-related deaths outnumber those caused by HIV/AIDS, tuberculosis, and malaria in U.S. priority countries., 
NCDs are sapping the economic strength and social capital of major U.S. partners in trade and development. The World Economic Forum continues to rank NCDs as one of the greatest risks to global well-being. Economic losses from NCDs are projected to reach $47 trillion over the coming 15 years. Much of this hampered economic growth is expected to occur in LMICs, further threatening education outcomes, workforce productivity, and progress toward global poverty eradication, including current and future development goals. Disabilities from NCDs account for 78.6% of all years lived with a disability, placing significant strains on both the disabled individual and the economy.
Preventing and managing NCDs creates an opportunity to improve maternal and child health outcomes. More than 25% of maternal deaths are caused by preexisting medical conditions such as diabetes, HIV, malaria, and obesity. For women living with NCDs, particularly Type 1 diabetes or rheumatic heart disease, preconception planning can help to reduce maternal and child morbidity and mortality. Early detection and management of gestational diabetes mellitus, for instance, can help to reduce the risk of stillbirth by up to 45% and the risk of later cardiometabolic disease for both mother and child. Postnatal follow-up also provides additional and beneficial screening opportunities.
NCDs affect all countries, but developing countries are affected disproportionally. Rather than diseases of age or affluence, NCDs are overwhelmingly diseases of poverty that strike early in life, impacting not just poor countries, but poorer populations in higher income countries. These populations face increased exposure to certain risk factors — for example, indoor air pollution from charcoal cooking stoves — along with insufficient resources to treat resulting health issues. Communicable diseases and NCDs not only coexist but, in many cases, influence the risk and progression of one another.